IK Multimedia recently announced their new range of Studio Monitors building on the iLoud range, which have built a reputation for sounding way bigger than they are. The new iLoud models are actually physically larger and are aimed squarely to be your main monitors. With the same DSP and room correction capabilities, they also have speaker profiles that can be stored and recalled, not for different rooms, but with emulations of different speaker sets.
Maybe a large TV or some other well known near field sounds to get a range of listening options from the same set of speakers. Presets can be selected from a nifty switcher box, or from the software control.
They aren't designed to be cheap though are do have a 'pro' price tag:
iLoud Precision 5 - 5