Using the master control on the POD in the 4-cable method really pushes the power amp. There is a reason why tube amps are popular.
The swampy, fat, grinding overdriven strat neck pickup tone is the best thing I've ever heard. With this setup, it's probably the best tone I've gotten thus far.
5:07 pushing the output tubes more
8:14 add delay
8:50 boosting with tube comp
11:40 SRV
14:15 That Strat TONE BABY