I was experimenting with the tele running straight into the 5E3. I absolutely love the connection between a tele and tweedy overdrive. The bright and spanky bridge pickup especially mates extremely well with the sleazy grind of the 5E3.
I haven't been able to play very much lately, so my fingers felt a bit sluggish in parts. But sometimes on a Sunday night you just have to let off some steam.
Enjoy!