Another very good model on this one. Two tips that I've picked up that help make all your tones sound better:
1. Set the mixer to 0 (center) for both sides and it really centers and focuses your sound
2. Put a digital delay in your effects chain with the delay time set to minimum and mix to maximum. EQ to taste and it helps space things out
I'm using my parts HSS strat and I use a little bit of the Tube Driver, Fuzz Face, and Deluxe Memory Man for some spice at the end.