I play a 2020 Friedman Twin Sister with a 1973 Fender Stratocaster. It has wonderful dynamics and string separation even at really high gain. At the end of the video I go through a bunch of different settings. I'm playing it through a 1971 Marshall 1960A Cab. I borrowed this amp from Boutique Amps Distribution.
Here is a Les Paul video on the Twin Sister as well.
https://www.youtube.com/watch?v=oNDyS4VJj74